NBA Picks and Predictions: Finest Bets for Wednesday October twenty second

After the defending NBA champion Oklahoma Metropolis Thunder and three fellow Western Convention contenders opened the season on Tuesday, a lot of the remainder of the league will get its flip Wednesday night time.

New eras and vibes abound in arenas and locker rooms.

As for the betting evaluation, it’s enterprise as normal.

Let’s see how these picks stack up on the Affiliation’s first busy night time of 2025-26.

CLEVELAND CAVALIERS at NEW YORK KNICKS, 7 p.m.

Many view these high-scoring assaults as the highest two contenders within the Jap Convention.

With a trio of Prime 20 scorers from final season concerned, this opener from Madison Sq. Backyard ought to a minimum of pack loads of factors.

New York’s Jalen Brunson (26 factors) and Karl-Anthony Cities (24.4) will intention to outdo Cleveland’s Donovan Mitchell (24.4), who has his share of operating mates.

Over 228.5 whole factors (-110 with BetMGM)

PHILADELPHIA 76ers at BOSTON CELTICS, 7:30 p.m.

Responding cheekily to The Ringer’s current listing omitting him from the league’s high 100 gamers, Sixers middle Joel Embiid stated, “I’m right here to assist,” after Philly’s preseason finale in opposition to Minnesota on Friday.

Because the group needs him wholesome for a hopeful postseason run, Embiid could also be extra inclined to help as a passer on the perimeter or on the elbow because the season begins. He’ll be a pressure inside, after all, albeit a selective one contemplating his two knee surgical procedures in 14 months and the mere 19 video games he performed in 2024-25.

“We received a bunch of athletes. We’ve received to launch them. … They’ve received to run,” Embiid stated. “My job is to search out them and, in a manner, that additionally type of saves me, as a result of if we get early baskets and straightforward baskets. I gained’t must run up and down. I can simply let these guys push the tempo, assault.”

Embiid averaged a career-best 5.6 assists in 39 video games in 2023-24 and confirmed a penchant for passing through the preseason, together with a team-best eight assists versus Minnesota. Anticipate the pattern – if not the cautious Embiid – to cross over.

Joel Embiid 7+ assists (+240 with BetMGM)

Celtics ahead Jaylen Brown insists the hamstring tightness that hampered him late in preseason was “simply possibly somewhat tweak however nothing loopy.”

As in not sufficient to sideline him for the opener of what shapes up as an odd season in Boston. Jayson Tatum (Achilles) is out indefinitely and a number of mainstays, headed by Al Horford, are also gone. Nonetheless, the Celtics boast depth and expertise to be a pressure on the periphery of a top-heavy Jap Convention.

As such, Brown is aware of he’ll appeal to a lot of defensive consideration and needs to be primed to take the reins on this one.

Jaylen Brown 25+ factors (-120 with BetMGM)

SAN ANTONIO SPURS at DALLAS MAVERICKS, 9:30 p.m.

Prime choose Cooper Flagg confronted a double-team on the primary possession of his first Summer season League recreation with Dallas, one sequence amongst a number of which have thrust him into the highlight.

He’s maintained a poise past his years all through the method, so why ought to Flagg’s common season debut be any totally different?

No rookie has captured a scoring title since Elvin Hayes in 1968-69, and it’s unlikely Flagg will crack that class. He’s fairly able to beginning his profession solidly, nonetheless, earlier than an amped up house crowd.

Cooper Flagg 15+ factors (-140 with BetMGM)