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Reading: Week 5 TNF: 49ers-Rams Preview, Props, Prediction
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Week 5 TNF: 49ers-Rams Preview, Props, Prediction
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Week 5 TNF: 49ers-Rams Preview, Props, Prediction

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Last updated: October 2, 2025 6:12 pm
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Published: October 2, 2025
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Dec 12, 2024; Santa Clara, California, USA; Los Angeles Rams quarterback Matthew Stafford (9) runs with the ball as San Francisco 49ers linebacker Fred Warner (54) defends within the fourth quarter at Levi’s Stadium. Necessary Credit score: Cary Edmondson-Imagn Photos

The San Francisco 49ers journey to Los Angeles on Thursday night time hoping an injury-riddled offense can maintain up towards the Rams’ ninth-ranked protection.

Los Angeles has produced 14 sacks and 20 tackles for loss by way of its 3-1 begin. San Francisco additionally enters 3-1, however will flip to backup Mac Jones for an important NFC West matchup with quarterback Brock Purdy sidelined by his nagging turf toe harm.

ODDS AND TRENDS

The 49ers’ offense can even be with out extensive receivers Jauan Jennings (ankle), Ricky Pearsall (knee) and Jordan Watkins (calf), with Brandon Aiyuk and tight finish George Kittle already on injured reserve. That has led to the Rams being a consensus 9.0-point favourite as of Thursday afternoon.

The road is 8.5 factors at BetRivers, the place 79 % of the spread-line cash is backing Los Angeles. The Rams’ -500 moneyline has additionally drawn one-sided motion with 88 % of the entire bets and 89 % of the cash.

The Rams have gained 15 of their previous 16 video games as favorites, whereas the 49ers have did not cowl the unfold in 13 of their previous 14 video games towards groups that entered with a successful file.

PROP PICKS

–Underneath 45.0 Whole Factors (-112 at BetRivers): Not solely is the 49ers’ offense decimated by accidents on the ability positions, however every of the Rams’ previous 5 video games as residence favorites have gone below the entire factors line.

–Rams RB Kyren Williams Anytime TD (-175 at DraftKings): Williams has scored a minimum of one landing in 9 consecutive residence video games towards NFC groups. For these in search of an even bigger payout, Williams has scored the primary TD in 5 of his previous six residence video games — and Williams scoring the primary TD on Thursday is being provided at +360.

RETURN OF THE MAC

It will mark Purdy’s third absence in 4 video games as a result of harm. He was initially harm throughout a Week 1 contest towards the Seattle Seahawks and aggravated the harm throughout final week’s 26-21 residence loss towards the Jacksonville Jaguars.

Jones began in Weeks 2 and three when Purdy was sidelined. Jones injured a knee throughout Week 3 however is now wholesome and was a full follow participant all week.

Jones is raring to take the sphere towards the Rams’ protection.

“I believe the way in which they play and their mindset,” Jones mentioned of what impresses him. “There are all the time 11 guys on the display they usually have an incredible defensive position. They play a number of protection schemes.

“It should be a problem. I am impressed with them so I am unable to wait to go towards them.”

Purdy remained hopeful Tuesday however might see his hopes beginning to slide.

“I haven’t got as many days to get proper and heal up and really feel higher,” Purdy mentioned.

INJURY REPORT

Together with Jennings, Pearsall and Watkins, 49ers defensive finish Robert Beal Jr. (ankle) additionally was declared out after not practising this week.

San Francisco defensive lineman CJ West (thumb) is questionable. He was a restricted participant on Wednesday.

Tight finish Tyler Higbee (hip) and offensive lineman Rob Havenstein (ankle) are listed as uncertain for the Rams. Neither participant practiced this week.

THEY SAID IT

“I believe they seem to be a actually well-rounded soccer staff, all the time have been. After we play them, it is a bare-knuckles bodily struggle. They’re gonna attempt to run the ball proper at you, play-action it excessive, and on protection, they’re gonna line up, know precisely what they’re in and simply attempt to out-physical you. So it is a massive problem for us, however a number of credit score to them as a result of they’ve completed a heck of a job with some accidents alongside the way in which early on.” — Rams quarterback Matthew Stafford, on going through the 49ers.

PREDICTION

San Francisco enters with the league’s sixth-ranked protection, however 2.0 of the staff’s 5.0 sacks up to now have come from now-injured defensive finish Nick Bosa. Alternative Bryce Huff has 2.0 as nicely, however the 49ers shall be hard-pressed to position the constant strain wanted to generate the a number of turnovers its beleaguered offense desperately wants. –Rams 23, 49ers 16

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