2025 NFL Odds Week 5: Traces, Spreads for all 14 Video games

NFL Week 5 kicks off Thursday night, as the Rams host the 49ers.

Here are the lines for every Week 5 matchup at DraftKings Sportsbook as of Sept. 30.

(All times ET)

2025 NFL Week 5 Odds

THURSDAY, OCT. 2

49ERS @ RAMS

Spread: Rams -5.5
Moneyline: Rams -258, 49ers +210
Total O/U: 47.5

SUNDAY, OCT. 5

VIKINGS @ BROWNS

Spread: Vikings -4.5
Moneyline: Vikings -198, Browns +164
Total O/U: 36.5

BRONCOS @ EAGLES

Spread: Eagles -4.5
Moneyline: Eagles -218, Broncos +180
Total O/U: 43.5

TEXANS @ RAVENS

Spread: Ravens -3.5
Moneyline: Ravens -185, Texans +154
Total O/U: 42.5

RAIDERS @ COLTS

Spread: Colts -6.5
Moneyline: Colts -305, Raiders +245
Total O/U: 47.5

COWBOYS @ JETS

Spread: Cowboys -3
Moneyline: Cowboys -145, Jets +130
Total O/U: 47.5

DOLPHINS @ PANTHERS

Spread: Panthers -1.5
Moneyline: Dolphins -102, Panthers -118
Total O/U: 45.5

GIANTS @ SAINTS

Spread: Giants -1.5
Moneyline: Giants +102, Saints -122
Total O/U: 40.5

BUCCANEERS @ SEAHAWKS

Spread: Seahawks -3
Moneyline: Seahawks -162, Buccaneers +136
Total O/U: 44.5

TITANS @ CARDINALS

Spread: Cardinals -8.5
Moneyline: Cardinals -455, +350
Total O/U: 41.5

LIONS @ BENGALS

Spread: Lions -10
Moneyline: Lions -520, Bengals +390
Total O/U: 49.5

COMMANDERS @ CHARGERS

Spread: Chargers -2.5
Moneyline: Chargers -142, Commanders +120
Total O/U: 47.5

PATRIOTS @ BILLS

Spread: Bills -8.5
Moneyline: Bills -410, Patriots +320
Total O/U: 50.5

MONDAY, OCT. 6

CHIEFS @ JAGUARS

Spread: Chiefs -3.5
Moneyline: Chiefs -192, Jaguars +160
Total O/U: 45.5

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